The tumor microenvironment and immune targeting therapy in pediatric renal tumors

Amy B Hont1, Benoit Dumont2, Kathryn S Sutton3

  • 1Department of Hematology/Oncology, Children's National Hospital, George Washington University, Washington, District of Columbia, USA.

Pediatric Blood & Cancer
|December 1, 2022
PubMed

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The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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