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Role of RAS signaling in ovarian cancer

Lubna Therachiyil1,2, Anjana Anand1, Abdullah Azmi1

  • 1Hamad Medical Corporation, Doha, Qatar, 3050, Qatar.

F1000Research
|December 1, 2022
PubMed

Insights

RAS proteins, frequently mutated in cancers, drive ovarian cancer (OC) growth and chemoresistance. KRAS mutations specifically are linked to poor outcomes in OC, highlighting their role in tumorigenesis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The RAS protein family is frequently mutated in human cancers.
  • RAS mutations, particularly KRAS at codons 12, 13, and 61, occur in 6-65% of ovarian cancer (OC) cases.
  • RAS proteins regulate critical cellular processes including proliferation, differentiation, invasion, and apoptosis.

Purpose of the Study:

  • To review recent literature on the role of oncogenic RAS in ovarian cancer.
  • To highlight the involvement of RAS in mediating carcinogenesis and chemoresistance in OC and its subtypes.

Main Methods:

  • Literature review of recent studies on RAS in ovarian cancer.

Main Results:

  • Aberrant RAS activation triggers downstream signaling pathways (e.g., MAPK, PI3K/AKT) promoting cell proliferation and survival.
  • KRAS mutations are associated with poor prognosis and chemoresistance in ovarian cancer.
  • RAS signaling contributes to tumorigenesis and cancer cell propagation in OC.

Conclusions:

  • Oncogenic RAS plays a significant role in ovarian cancer development and progression.
  • Understanding RAS involvement is crucial for developing targeted therapies for OC subtypes.
  • KRAS mutation status can serve as a predictive biomarker for treatment response in ovarian cancer.
Keywords:
OncogeneOvarian cancersRAScell signalingmutation

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