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Frequency-tuned electromagnetic field therapy improves post-stroke motor function: A pilot randomized controlled

Batsheva Weisinger1, Dharam P Pandey2, Jeffrey L Saver3

  • 1BrainQ Technologies, Ltd., Jerusalem, Israel.

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Summary
This summary is machine-generated.

Electromagnetic Network Targeting Field (ENTF) therapy significantly improved upper extremity motor function in subacute ischemic stroke patients. This non-invasive treatment also reduced overall disability without reported adverse events.

Keywords:
ELF-EMFENTFNIBSischemic strokemagnetic field therapyneurorecoveryneurostimulationupper extremity motor function

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Biophysics

Background:

  • Impaired upper extremity (UE) motor function is a prevalent disability following ischemic stroke.
  • Non-invasive therapies that enhance neuroplasticity are crucial for motor recovery.
  • Extremely low frequency and low intensity electromagnetic fields (ELF-EMF) offer a potential therapeutic approach.

Purpose of the Study:

  • To quantify the benefit of Electromagnetic Network Targeting Field (ENTF) therapy on UE motor function in subacute ischemic stroke patients.
  • To evaluate the efficacy of a novel, non-invasive brain computer interface-based ENTF therapy.
  • To assess the safety and effectiveness of ENTF therapy in improving motor deficits.

Main Methods:

  • A randomized, sham-controlled, double-blind trial was conducted.
  • Subacute ischemic stroke patients with moderate to severe UE impairment received active or sham ENTF therapy (1-100 Hz, < 1 G) for 8 weeks, 5 days/week.
  • Concurrent physical/occupational therapy was provided for approximately three out of five sessions weekly.

Main Results:

  • ENTF therapy demonstrated significantly greater improvement in UE motor function compared to sham treatment, as measured by the Fugl-Meyer Assessment - Upper Extremity (FMA-UE) at week 4 (p=0.007) and week 8.
  • Significant improvements were also observed in other UE assessments, including the Action Research Arm Test (p=0.008) and Box and Blocks Test (p<0.0001).
  • ENTF therapy was associated with a reduction in overall disability, indicated by a significant improvement in the modified Rankin Scale (p=0.0005), with no reported adverse events.

Conclusions:

  • ENTF stimulation is associated with improved UE motor function and reduced overall disability in subacute ischemic stroke patients.
  • The findings support the safe use of ENTF therapy in this patient population.
  • Larger multicenter studies are recommended to confirm these promising results.