Related Experiment Video
Updated: Aug 19, 2025
07:15
Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research
Published on: December 18, 2020
4.6K
Lipid-Based Intelligent Vehicle Capabilitized with Physical and Physiological Activation
Fuxue Zhang1,2, Bozhang Xia1,3, Jiabei Sun4
1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing 100190, China.
Research (Washington, D.C.)
|December 1, 2022
Summary
Intelligent drug delivery systems using "stimulus-response" lipid nanoparticles offer new possibilities. These systems utilize physical or physiological signals for efficient, on-demand drug release.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Drug Delivery Systems
Background:
- Lipid-based nanoparticles are crucial for advanced drug delivery.
- Stimulus-responsive systems enhance therapeutic efficacy and reduce side effects.
- Intelligent drug delivery requires precise control over release mechanisms.
Purpose of the Study:
- To classify and review "stimulus-response" mechanisms in intelligent drug delivery.
- To explore the application of physical and physiological stimuli in nanoparticle-based drug delivery.
- To provide a future outlook on advanced drug delivery systems.
Main Methods:
- Classification of stimuli into physical (temperature, ultrasound, electromagnetic wave) and physiological (pH, redox, proteins).
- Summarization of external physical response based on efficiency, particle state, and on-demand release.
- Description of in vivo drug delivery design using physiological environments and current applications.
Main Results:
- Physical stimuli offer control over nanoparticle efficiency, state, and release.
- Physiological stimuli enable targeted drug delivery within the body.
- Diverse application methods for intelligent drug delivery systems are presented.
Conclusions:
- Stimulus-responsive lipid nanoparticles represent a promising frontier in drug delivery.
- Understanding signal sources is key to designing effective intelligent delivery systems.
- Future developments will likely focus on integrated and multi-stimuli responsive systems.
Related Concept Videos
01:31Lipid-derived Compounds in the Human Body
4.6K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.6K
01:24Lipid Absorption
588
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
588
01:20Motor Unit Stimulation
1.7K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
1.7K
01:14Design Example: Automobile Ignition System
277
The automobile's ignition system plays a vital role by ensuring the timely ignition of the fuel-air mixture in each cylinder. This ignition is facilitated by a spark plug, which is composed of two electrodes separated by an air gap. A spark forms across this air gap when a substantial voltage is generated between the electrodes, leading to the ignition of the fuel.
One can generate a large voltage using a car battery of 12 volts with the help of inductors. Inductors are known for opposing...
One can generate a large voltage using a car battery of 12 volts with the help of inductors. Inductors are known for opposing...
277