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Expression of Marker PAK1 in Sinonasal Polyposis
Somu Lakshmanan1, Rashmika Rajendran2, Sathishkumar Jayagandhi1
1Department of ENT and Head and Neck Surgery, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu India.
Summary
Chronic rhinosinusitis with nasal polyposis shows increased PAK1 expression. This suggests PAK1 may play a role in the inflammation and cell growth characteristic of this condition.
Area of Science:
- Immunology
- Otolaryngology
- Cell Biology
Background:
- Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects the nasal and paranasal sinus mucosa.
- Inflammatory mechanisms driving leukocyte recruitment and activation are key to CRSwNP pathogenesis.
Purpose of the Study:
- To investigate and compare the expression of the immunohistochemistry marker PAK1.
- To differentiate PAK1 expression between sinonasal polyposis tissue and normal nasal mucosa.
Main Methods:
- A prospective observational study design was employed.
- Two groups of 30 participants each were compared: Group A (sinonasal polyposis) and Group B (normal nasal mucosa).
- PAK1 immunohistochemical staining was performed on tissue specimens.
Main Results:
- Immunohistochemical staining revealed a higher intensity of PAK1 expression in sinonasal polyps.
- Compared to normal nasal mucosa, sinonasal polyps exhibited significantly greater PAK1 staining.
Conclusions:
- PAK1 is upregulated in sinonasal polyposis.
- This upregulation may indicate increased cellular proliferation and turnover.
- PAK1 upregulation is associated with the chronic inflammatory background of CRSwNP.
