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A Review on Esthesioneuroblastoma
Kartika Ramesh Rao1, Ila B Upadhya1
1Department of E.N.T., Government Medical College and New Civil Hospital, Surat, India.
Summary
Esthesioneuroblastoma (ENB), a rare sinonasal tumor, requires multidisciplinary management. Optimal treatment involves surgery and radiotherapy, with chemotherapy
Area of Science:
- Oncology
- Otorhinolaryngology
- Pathology
Background:
- Esthesioneuroblastoma (ENB) is a rare, aggressive sinonasal malignancy.
- Despite existing research, significant knowledge gaps persist regarding ENB.
- Its unique characteristics warrant continued investigation.
Purpose of the Study:
- To review current literature on esthesioneuroblastoma.
- To document contemporary management practices for ENB.
- To provide an overview of diagnosis and treatment.
Main Methods:
- Comprehensive literature review utilizing Google Scholar and PubMed.
- Keywords included: esthesioneuroblastoma, olfactory neuroblastoma, Kadish, Hyams.
- English articles published up to April 2021 were analyzed.
Main Results:
- ENB exhibits diverse histology and a bimodal age distribution, with no gender predilection.
- Accurate diagnosis relies on immunohistochemistry.
- Multi-modality treatment, particularly surgery and radiotherapy, yields better outcomes than uni-modality approaches.
Conclusions:
- Prompt diagnosis and multidisciplinary collaboration (radiology, pathology, rhinology) are crucial for favorable outcomes.
- Staging and prognosis depend on regional involvement due to ENB's proximity to neurological structures.
- Extended follow-up is recommended for all ENB patients.
