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Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

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Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during

Eliah G Overbey^1,2, Saswati Das³, Henry Cope⁴

¹Weill Cornell Medicine, New York, NY, USA.

Cell Reports Methods

|December 1, 2022

Summary

This summary is machine-generated.

Single-cell RNA sequencing and spatially resolved transcriptomics are crucial for space biology. This perspective discusses their growing importance and challenges for spaceflight gene expression studies.

Keywords:

RNA-sequencing single-cell spaceflight spatial spatially resolved transcriptomics transcriptomics

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Last Updated: Aug 19, 2025

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

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Published on: January 13, 2019

Transcriptome Analysis of Single Cells

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

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Published on: July 6, 2022

Area of Science:

Space biology
Molecular biology
Genomics

Background:

Single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) are rapidly advancing technologies.
These methods offer powerful tools for understanding biological systems at high resolution.
Their application in space biology is crucial for understanding life in space.

Purpose of the Study:

To highlight the increasing significance of scRNA-seq and SRT in space biology.
To identify challenges and considerations for experimental design in spaceflight.
To promote the growth and adoption of these methods in the field of space biology.

Main Methods:

Review of current spaceflight gene expression datasets.
Analysis of the limited application of scRNA-seq and SRT in space biology.
Discussion of experimental design principles for spaceflight transcriptomics.

Main Results:

Few existing spaceflight gene expression datasets utilize scRNA-seq and SRT.
Significant potential exists for scRNA-seq and SRT to advance understanding of space biology.
Key challenges in spaceflight experimental design need to be addressed.

Conclusions:

scRNA-seq and SRT are vital for future space biology research.
Addressing experimental design challenges is essential for successful spaceflight applications.
Further development and implementation of these techniques will enhance our understanding of gene expression in space.