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Related Experiment Video

Updated: Aug 19, 2025

One-day Workflow Scheme for Bacterial Pathogen Detection and Antimicrobial Resistance Testing from Blood Cultures
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An algorithm for PCT-guided antimicrobial therapy: a consensus statement by Japanese experts.

Akihiro Ito1, Nobuaki Shime2, Seitaro Fujishima3

  • 1Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan.

Clinical Chemistry and Laboratory Medicine
|December 1, 2022
PubMed
Summary
This summary is machine-generated.

Japanese experts adapted procalcitonin (PCT)-guided therapy algorithms to reduce antibiotic use in hospitalized patients. This strategy aims to combat antimicrobial resistance (AMR) safely within Japan

Keywords:
PCT-guided therapyalgorithmantimicrobial stewardshipantimicrobial-resistant pathogensprocalcitonin

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Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Public Health Policy

Background:

  • Japan's 2016 national antimicrobial resistance (AMR) action plan aims to reduce antibiotic consumption.
  • Despite efforts, further reduction is needed to meet the 20% goal by 2020.
  • Procalcitonin (PCT)-guided therapy is a proven method to reduce antibiotic use in acute respiratory infections.

Purpose of the Study:

  • To adapt international PCT-guided therapy algorithms for Japanese medical circumstances.
  • To facilitate safe reduction of antibiotic consumption in Japan.
  • To mitigate the spread of antimicrobial resistance (AMR) pathogens.

Main Methods:

  • Modification of international PCT-guided therapy algorithms by Japanese experts.
  • Inclusion of specialists from intensive care, emergency, respiratory, and infectious diseases.
  • Adaptation focused on hospitalized ICU and non-ICU patients, excluding specific bacterial pneumonias, and adjusting PCT follow-up timing.

Main Results:

  • Development of a modified PCT-guided algorithm tailored for Japan.
  • The algorithm addresses Japanese medical and insurance system constraints.
  • Potential for significant improvement in safe antibiotic reduction and AMR containment.

Conclusions:

  • The adapted PCT-guided algorithm offers a viable strategy for Japan.
  • It supports the national goal of reducing antibiotic consumption.
  • This approach is expected to aid in combating antimicrobial resistance.