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Related Experiment Video

Updated: Aug 19, 2025

Author Spotlight: Cardiac Cell Transgenesis for Rapid Gene Screening

Author Spotlight: Cardiac Cell Transgenesis for Rapid Gene Screening

Published on: May 24, 2024

Genome Editing and Myocardial Development.

Sifa Turan¹, J Richard Chaillet^1,2, Margaret C Stapleton^3,4

¹Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

Advances in Experimental Medicine and Biology

|December 1, 2022

Summary

This summary is machine-generated.

Genetic editing offers a promising therapeutic approach for congenital heart disease (CHD), a condition with significant genetic causes. Research explores gene editing in mouse models to understand and potentially correct the genetic mutations responsible for CHD.

Keywords:

Cardiovascular disease Congenital heart disease (CHD)Heart development

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Area of Science:

Cardiovascular Genetics
Developmental Biology
Gene Editing Technologies

Background:

Congenital heart disease (CHD) affects up to 1% of live births, with complex genetic origins involving over 400 genes crucial for myocardial development.
Genetic mutations in intricate networks disrupt cardiovascular formation, leading to various heart abnormalities.

Approach:

This review examines the anatomical and genetic timelines of myocardial development in humans and mice.
It evaluates the potential of genome editing for treating syndromic, nonsyndromic, and familial CHD cases with identifiable mutations.
The role of mouse models in replicating human CHD and testing gene correction strategies is discussed.

Key Points:

Genome editing technologies present a viable future therapeutic strategy for CHD.
Identifiable genetic mutations in various CHD forms indicate potential targets for gene therapy.
Mouse models are instrumental in studying CHD pathogenesis and validating gene editing approaches.

Conclusions:

CHD's strong genetic basis makes it a prime candidate for gene editing therapies.
Advancements in genome editing technology hold promise for correcting causative mutations in CHD.
Further research using established mouse models will facilitate the clinical translation of gene editing for CHD treatment.