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Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

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Updated: Aug 19, 2025

Author Spotlight: Cardiac Cell Transgenesis for Rapid Gene Screening

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Published on: May 24, 2024

Genome Editing and Heart Failure.

Daniele Masarone¹, Martina Caiazza², Federica Amodio²

¹Heart Failure Unit, Department of Cardiology, AORN dei Colli, Monaldi Hospital, Naples, Italy. danielemasarone@ospedalideicolli.it.

Advances in Experimental Medicine and Biology

|December 1, 2022

Summary

This summary is machine-generated.

Heart failure, a major global health issue, involves cardiac abnormalities. Genome editing offers potential to correct genetic defects and improve heart function in patients.

Keywords:

Beneficial therapeutic effect Disease models Genome editing Heart failure

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Published on: October 3, 2019

Area of Science:

Cardiology
Genetics
Biotechnology

Background:

Heart failure is a significant cause of global morbidity and mortality.
Risk factors for heart failure with reduced ejection fraction overlap with chronic coronary syndrome.
Genetic predisposition to cardiomyopathies contributes to heart failure development.

Purpose of the Study:

To explain the pathophysiology and genetics of heart failure.
To discuss the clinical applications of genome editing for heart failure treatment.

Main Methods:

Review of pathophysiological and genetic aspects of heart failure.
Exploration of genome editing technologies for genetic defect correction.
Discussion of genome editing applications in clinical settings.

Main Results:

Genome editing technologies can correct specific mutations causing cardiomyopathies.
These technologies hold potential for modulating and improving cardiac function.
Clinical applications of genome editing in heart failure are being explored.

Conclusions:

Genome editing presents a promising therapeutic avenue for heart failure.
Targeting genetic defects offers a novel approach to managing heart failure.
Further research is needed to fully realize the clinical potential of genome editing in cardiology.