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Genome Editing and Obesity.

Davide Masi1, Rossella Tozzi2, Mikiko Watanabe3

  • 1Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

Advances in Experimental Medicine and Biology
|December 1, 2022
PubMed
Summary
This summary is machine-generated.

Obesity, a chronic metabolic disease, involves complex genetic, behavioral, and environmental factors. Genome editing technologies like CRISPR/Cas offer promising new avenues for understanding and treating obesity by targeting its genetic underpinnings.

Keywords:
CRISPRFatGWASGenomeNutritionObesityWaist circumference

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Area of Science:

  • Genetics and Metabolic Disorders
  • Biotechnology and Gene Editing

Background:

  • Obesity is a complex metabolic illness linked to numerous diseases, influenced by genetics, behavior, and environment.
  • Genome-wide association studies (GWASs) have identified multiple genes associated with obesity.
  • Current understanding highlights the need for novel therapeutic strategies beyond traditional weight management.

Purpose of the Study:

  • To summarize the genetic basis of obesity.
  • To review existing obesity treatments.
  • To discuss the advancements and potential of genome editing for obesity research and treatment.

Main Methods:

  • Review of genetic studies, including GWASs, implicating specific genes in obesity.
  • Analysis of current therapeutic approaches for managing obesity.
  • Exploration of genome editing technologies, specifically CRISPR/Cas, for genetic manipulation in obesity research.

Main Results:

  • Several genes have been identified as contributors to obesity through GWASs.
  • Genome editing technologies, such as CRISPR/Cas, show potential for understanding obesity's genetic mechanisms.
  • CRISPR/Cas offers a promising tool for developing novel obesity treatments by targeting gene expression or DNA.

Conclusions:

  • Obesity is a multifactorial disease with a significant genetic component.
  • Genome editing, particularly CRISPR/Cas, represents a cutting-edge approach for advancing obesity research.
  • The application of genome editing holds promise for future therapeutic interventions in managing excess body fat.