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Related Concept Videos

Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

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Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

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The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Related Experiment Video

Updated: Aug 19, 2025

Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart
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Gene Therapy and Cardiovascular Diseases.

Dongchao Lu1, Sarah Cushman1, Thomas Thum1,2,3

  • 1Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany.

Advances in Experimental Medicine and Biology
|December 1, 2022
PubMed
Summary

Gene therapy offers novel strategies for cardiovascular diseases (CVDs), the leading global cause of death. This review covers gene modulation technologies and clinical trials for treating CVDs.

Keywords:
Cardiovascular diseasesGene therapyRNA therapy

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Area of Science:

  • Cardiovascular Medicine
  • Molecular Biology
  • Biotechnology

Background:

  • Cardiovascular diseases (CVDs) represent a significant global health burden, necessitating innovative therapeutic approaches.
  • Gene therapy, involving the modulation of gene expression, presents a promising avenue for treating genetic and acquired cardiovascular conditions.

Purpose of the Study:

  • To review current gene therapy technologies applicable to cardiovascular diseases.
  • To summarize recent clinical trials investigating gene therapy for CVDs.
  • To discuss the potential applications and challenges of gene therapy in managing cardiovascular conditions.

Main Methods:

  • Literature review of state-of-the-art gene therapy technologies.
  • Analysis of recent clinical trial data for gene therapy in CVDs.
  • Discussion of gene delivery systems (viral and nonviral) and gene modulation tools (plasmids, oligos, CRISPR/Cas).

Main Results:

  • Gene therapy encompasses various approaches including viral/nonviral delivery and gene editing tools like CRISPR/Cas.
  • Multiple gene therapy strategies are under investigation in clinical trials for CVDs.
  • The field is rapidly advancing, with ongoing efforts to optimize efficacy and safety.

Conclusions:

  • Gene therapy holds significant potential for the future treatment of cardiovascular diseases.
  • Understanding current technologies and clinical trial outcomes is crucial for advancing the field.
  • Translating gene therapy from bench to bedside requires addressing delivery, specificity, and long-term effects.