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Substrate-selective small-molecule modulators of enzymes: Mechanisms and opportunities

Hening Lin1

  • 1Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.

Current Opinion in Chemical Biology
|December 1, 2022
PubMed

Keywords:
COX-2Chemical geneticsGamma-secretaseInsulin degrading enzymeReverse chemical geneticsSIRT2SIRT6SirtuinsSubstrate-dependent inhibitionSubstrate-selective inhibition

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