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Antiplatelet Therapy in Coronary Artery Disease: Now and Then

Maximilian Tscharre1,2, Thomas Gremmel2,3,4

  • 1Department of Internal Medicine, Cardiology and Nephrology, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria.

Seminars in Thrombosis and Hemostasis
|December 1, 2022
PubMed

Insights

Cardiovascular disease, like coronary artery disease, is a major health issue. Antiplatelet therapy is crucial for managing this condition by preventing blood clots.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Thrombosis Research

Background:

  • Coronary artery disease (CAD) is a primary cause of death and illness globally.
  • Platelet activation and aggregation are central to thrombus formation and vessel occlusion in CAD.
  • Antiplatelet therapy is a fundamental treatment for CAD.

Approach:

  • This review traces the historical development of antiplatelet therapies.
  • It examines both past and present antiplatelet medications and treatment strategies.
  • The focus is on the evolution and current landscape of antiplatelet agents.

Key Points:

  • Platelet function is critical in the pathogenesis of CAD.
  • A variety of antiplatelet drug classes are available for clinical use.
  • Understanding the evolution of these therapies informs current treatment approaches.

Conclusions:

  • Antiplatelet therapy has significantly evolved to combat CAD.
  • A comprehensive overview of antiplatelet drugs and strategies is presented.
  • This review highlights the ongoing importance of antiplatelet agents in cardiovascular medicine.

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