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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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Alterations in the omics profiles in mevalonate pathway-inhibited cancer cells

Tomoko Warita1, Nanami Irie2, Yaxuan Zhou2

  • 1Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo 669-1330, Japan.

Life Sciences
|December 1, 2022
PubMed
Abstract

Insights

Statins show potential against cancer by affecting cell cycle and DNA replication. Combining statins with metabolic pathway inhibitors may enhance their antitumor effects in lung cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Statins, cholesterol-lowering drugs, are investigated for their potential to inhibit cancer proliferation.
  • Mechanisms of statin action, tumor cell responses, and antitumor effects require further elucidation.

Purpose of the Study:

  • To investigate the effects of statins on cancer cells.
  • To compare responses between statin-sensitive and statin-resistant lung cancer cells.

Main Methods:

  • Transcriptome and metabolome analyses were performed on atorvastatin-treated lung cancer cells.
  • Gene Ontology and pathway enrichment analyses were utilized.

Main Results:

  • Atorvastatin treatment decreased cell cycle and DNA replication gene expression in statin-sensitive cells.
  • Metabolome analysis revealed decreased polyamine, purine metabolism, glycolysis, and pentose phosphate pathways in statin-sensitive cells.

Conclusions:

  • Differences between sensitive and resistant cells highlight potential therapeutic targets.
  • Inhibiting specific metabolic pathways alongside statins may improve anticancer efficacy.
Keywords:
Cancer cellsGlycolysisMetabolomePolyamine metabolismStatinsTranscriptome

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