Related Experiment Video

Updated: Aug 19, 2025

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

9.8K

Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management

Noa Mandel-Shorer1, Christine A Sabapathy2, Pradeep Krishnan3

  • 1Department of Pediatric Hematology-Oncology, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Seminars in Pediatric Neurology
|December 1, 2022
PubMed

Insights

Cerebral sinovenous thrombosis (CSVT) in children is serious but treatable. This review discusses ongoing debates and uncertainties in anticoagulation therapy for pediatric CSVT, highlighting the need for evidence-based guidelines.

Area of Science:

  • Neurology
  • Hematology
  • Pediatrics

Background:

  • Cerebral sinovenous thrombosis (CSVT) is a rare but severe condition in children, potentially causing significant neurological issues.
  • Current guidelines recommend early diagnosis and anticoagulation for pediatric CSVT.
  • However, a lack of clinical trials leads to uncertainties in treatment protocols.

Approach:

  • This review examines common challenges and controversies in pediatric CSVT anticoagulation.
  • It focuses on issues debated by pediatric neurologists and hematologists.
  • The review synthesizes current understanding and identifies areas needing further research.

Key Points:

  • Evidence-based selection criteria for anticoagulation in pediatric CSVT are lacking.
  • Optimal anticoagulant choice, monitoring, and treatment duration remain debated.
  • Consensus guidelines highlight the need for prompt anticoagulation but lack trial support.

Conclusions:

  • Significant uncertainties persist regarding anticoagulation practices for pediatric CSVT.
  • Further clinical trials are essential to establish evidence-based treatment protocols.
  • Addressing these debates is crucial for optimizing pediatric CSVT management.

More Related Videos

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method08:07

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method

Published on: July 4, 2021

3.6K
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

10.6K

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
16
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
19
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
30
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
24
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
16