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Analysis of mortality risk factors in children with severe adenovirus pneumonia: A single-center retrospective study

Xue-Hua Xu1, Hui-Feng Fan1, Ting-Ting Shi2

  • 1Department of Respiratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Pediatrics and Neonatology
|December 1, 2022
PubMed

Insights

In children with severe adenovirus pneumonia, infants under one year old face higher mortality risks. Hypoxia and low platelet counts are identified as key risk factors for mortality in these young patients.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Human adenovirus (HAdV) commonly causes respiratory infections in children, often mild but sometimes severe.
  • Severe adenovirus pneumonia can be fatal, yet mortality risk factors remain unclear.
  • Understanding these factors is crucial for timely intervention and improved outcomes.

Purpose of the Study:

  • To identify independent mortality risk factors in children diagnosed with severe adenovirus pneumonia.
  • To provide data that can inform clinical management and risk stratification.

Main Methods:

  • A retrospective study was conducted involving children hospitalized with severe adenovirus pneumonia.
  • Data from July 2018 to January 2020 were analyzed using binary logistic regression after univariate analysis.

Main Results:

  • The study included 189 children, with a 6.88% mortality rate (13 deaths).
  • Independent mortality risk factors identified were: age < 1 year (OR=18.513), hypoxia (OR=62.335), and thrombocytopenia (platelet <100×10^9/L) (OR=13.324).

Conclusions:

  • Age less than one year is a significant risk factor for mortality in severe adenovirus pneumonia.
  • Hypoxia and thrombocytopenia (platelet count <100×10^9/L) are independent predictors of mortality in affected children.
Abstract

Keywords:
childrenmortalityrisk factorssevere adenovirus pneumonia

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