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Understanding the role of Cripto-1 in cancer progression and therapeutic strategies

Qingfang Zeng1, Yuzhen Gao2, Ying Zhou3

  • 1Department of Gastroenterology, The 910 Hospital of Joint Logistic, Support Force Hua-Yuan Road No.180, Quanzhou City, Fujian Province, 362000, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|December 1, 2022
PubMed

Insights

Cripto-1 protein drives human growth but promotes cancer metastasis by initiating epithelial to mesenchymal transition (EMT). This review explores Cripto-1

Area of Science:

  • Developmental Biology
  • Cancer Biology
  • Molecular Oncology

Background:

  • Cripto-1 is a crucial protein in embryonic development, regulating epithelial to mesenchymal transition (EMT).
  • Elevated Cripto-1 levels are observed in most malignancies, correlating with tumor progression.
  • Cripto-1 facilitates cell migration and metastasis by inducing EMT.

Purpose of the Study:

  • To elucidate the role of Cripto-1 in common human cancers.
  • To review therapeutic strategies targeting Cripto-1 for cancer treatment.

Main Methods:

  • Review of existing literature on Cripto-1 function in embryogenesis and cancer.
  • Analysis of Cripto-1's mechanisms in promoting epithelial to mesenchymal transition (EMT).
  • Summary of therapeutic interventions aimed at inhibiting Cripto-1 activity.

Main Results:

  • Cripto-1's dual role: essential for embryonic growth but detrimental in cancer metastasis.
  • Cripto-1 facilitates cancer cell migration through EMT, enabling invasion and spread.
  • High Cripto-1 expression is a hallmark of many malignant tumors.

Conclusions:

  • Cripto-1 is a significant factor in cancer progression and metastasis.
  • Targeting Cripto-1 offers a promising therapeutic avenue for various cancers.
  • Further research into Cripto-1-based therapies is warranted.
Keywords:
CancerCancer therapyCripto-1EMT

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