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Updated: Aug 19, 2025

Three-Dimensional Shape Modeling and Analysis of Brain Structures
Published on: November 14, 2019
TemplateFlow: FAIR-sharing of multi-scale, multi-species brain models
Rastko Ciric1,2, William H Thompson3,4,5, Romy Lorenz3,6,7
1Department of Psychology, Stanford University, Stanford, CA, USA. rastko@stanford.edu.
Abstract:
Reference anatomies of the brain ('templates') and corresponding atlases are the foundation for reporting standardized neuroimaging results. Currently, there is no registry of templates and atlases; therefore, the redistribution of these resources occurs either bundled within existing software or in ad hoc ways such as downloads from institutional sites and general-purpose data repositories. We introduce TemplateFlow as a publicly available framework for human and non-human brain models. The framework combines an open database with software for access, management, and vetting, allowing scientists to share their resources under FAIR-findable, accessible, interoperable, and reusable-principles. TemplateFlow enables multifaceted insights into brains across species, and supports multiverse analyses testing whether results generalize across standard references, scales, and in the long term, species.
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