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Updated: Aug 19, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Ni-Catalyzed Reductive Coupling of Heteroaryl Bromides with Tertiary Alkyl Halides
Quan Lin1,2, Hegui Gong2, Fan Wu3
1School of Materials Science and Engineering, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.
Abstract:
We disclose here a nickel-catalyzed reductive coupling of bromopyridines with tertiary alkyl bromides for the synthesis of alkylated pyridines bearing an all-carbon quaternary center. This strategy features mild conditions, broad substrate scope, and high functional group tolerance. The method reported here offers an alternative solution to the challenging task of forging sterically congested alkylpyridines, which we believe will significantly benefit the synthetic community and pharmaceutical industry.
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