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Arterial hypertension in systemic sclerosis
Ewa Wielosz1, Magdalena Dryglewska1, Anna Górak1
1Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland.
Postepy Dermatologii I Alergologii
|December 2, 2022
Summary
Arterial hypertension (AH) is common in systemic sclerosis (SSc), affecting 41.7% of patients. This condition is linked to more severe disease, including increased mortality and kidney problems.
Area of Science:
- Rheumatology
- Cardiology
- Nephrology
Background:
- Arterial hypertension (AH) is a frequent comorbidity in systemic connective tissue diseases.
- Understanding AH in systemic sclerosis (SSc) is crucial for patient management.
Purpose of the Study:
- To determine the incidence of AH in patients with SSc.
- To describe the clinical features of SSc patients diagnosed with AH.
Main Methods:
- A cohort of 108 SSc patients was divided into two groups: with AH (n=45) and without AH (n=63).
- Evaluated serological profile, scleroderma renal crisis, organ involvement, mortality, kidney function (creatinine, eGFR), and uric acid levels.
Main Results:
- AH was diagnosed in 41.7% of SSc patients.
- AH (+) group showed significantly higher age, incidence of esophageal involvement, digital ulcerations, and mortality.
- Higher prevalence of chronic kidney disease (CKD) stages 2 and 3 in AH (+) group; stages 4-5 CKD only in AH (+) patients.
- Elevated uric acid was more common in the AH (+) group.
Conclusions:
- AH is a common complication in SSc patients.
- AH in SSc is associated with a more severe disease course and a higher frequency of renal complications.
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