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Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis
Anna Zaryczañska1, Jolanta Gleñ1, Monika Zabłotna1
1Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.
Introduction:
Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).
Aim:
To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD.
Material And Methods:
The study group consisted of 191 patients with AD and 168 controls.
Results:
The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24-35.99, p = 0.01).
Conclusions:
The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.
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