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Related Experiment Video

Updated: Aug 19, 2025

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
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Bibliometric and visual analysis of coronary microvascular dysfunction.

Xiaoxiao Lin1, Guomin Wu2, Beibei Gao2

  • 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in Cardiovascular Medicine
|December 2, 2022
PubMed
Summary

This bibliometric analysis reveals that coronary microvascular dysfunction (CMD) research is growing, with key focus on heart failure with preserved ejection fraction (HFpEF) and diagnostic advancements. Further international collaboration is encouraged to expand the field.

Keywords:
HFpEFbibliometric analysiscoronary microvascular dysfunction (CMD)treatmentvisual maps

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Area of Science:

  • Cardiovascular Research
  • Bibliometrics
  • Medical Informatics

Background:

  • Coronary microvascular dysfunction (CMD) is implicated in various cardiovascular diseases, including heart failure with preserved ejection fraction (HFpEF) and coronary artery disease (CAD).
  • Existing literature lacks a comprehensive bibliometric analysis to map the research landscape of CMD.
  • This study provides the first bibliometric overview of CMD research to identify current trends and future directions.

Purpose of the Study:

  • To conduct a bibliometric analysis of coronary microvascular dysfunction (CMD) research.
  • To identify leading authors, institutions, and countries contributing to the field.
  • To determine research hotspots and emerging trends in CMD.

Main Methods:

  • Bibliometric analysis of publications from the Web of Science Core Collection (WOSCC).
  • Utilized VOSviewer 1.6.16 and CiteSpace 5.1.3 for data analysis.
  • Included 785 publications (206 reviews, 579 articles) from 2012-2021.

Main Results:

  • The USA, Italy, and England are the leading countries in CMD research.
  • Key research areas include CMD in HFpEF, sex differences, diagnostic methods, and treatment.
  • Prominent keywords include heart failure, hypertrophic cardiomyopathy, chest pain, women, coronary flow reserve (CFR), and endothelial dysfunction.
  • "Positron emission tomography" and "coronary flow reserve" show significant burst activity.

Conclusions:

  • CMD research is concentrated in a few countries, necessitating broader international participation.
  • Future research should prioritize understanding CMD in HFpEF, exploring sex-based differences, and developing novel diagnostic and therapeutic strategies.
  • Investigating the link between CMD and HFpEF may facilitate personalized treatment approaches.