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Updated: Aug 19, 2025

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Published on: August 15, 2022
Transfusion-Related Acute Lung Injury Caused by HLA-II Antibodies: A Case Report
Xinxin Hao1, Jue Wang2, Tiegang Li3
1Department of Blood Transfusion, Shengjing Hospital of China Medical University, Shenyang, Liaoning, 110004, China.
Objective:
The aim of this study was to retrospectively analyze the etiology of a case of suspected transfusion-related acute lung injury (TRALI) occurring after blood transfusion.
Methods:
The clinical symptoms, signs, imaging examinations, and laboratory test results of a patient with suspected TRALI after blood transfusion were retrospectively analyzed, and human leukocyte antigen (HLA) genotyping of the patient and HLA antibodies of the plasma donors were performed.
Results:
The clinical manifestations of the patient were consistent with those of TRALI after blood transfusion. This TRALI was treated by timely ventilator support. The patient results of high-resolution HLA genotyping were HLA-A* 01:01, 11:01; HLA-B* 15:02, 37:01; HLA-C* 06:02, 08:01; DRB1* 10:01, 12:02; DRB3* 03:01, 03:01; DQA1* 01:05, 06:01; DQB1* 03:01, 05:01; DPA1* 01:03, 02:01; and DPB1* 02:01, 09:01. Of the 6 plasma donors tested, 3 were found to have HLA-II antibodies, which were HLA-DPA1*01:03, HLA-DQB1*03:01, and HLA-DQB1*03:01 antibodies.
Conclusion:
We described a case of TRALI caused by HLA-DQB1*03:01 antibody and DPA1*01:03 antibody.
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