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Statins improve asthma symptoms by suppressing inflammation: a meta-analysis based on RCTs
1Division of Respiratory Medicine, Digestive Internal Medicine, The First People's Hospital of Fuyang Hangzhou, Hangzhou, China. xuqinxing@yeah.net.
European Review for Medical and Pharmacological Sciences
|December 2, 2022
Summary
Statins improved asthma symptoms and reduced inflammation markers like hsCRP and IL-6. However, this meta-analysis found no significant impact on lung function in asthma patients.
Area of Science:
- Pulmonary Medicine
- Pharmacology
- Inflammation Research
Background:
- Asthma is a chronic airway inflammatory disease characterized by the infiltration of inflammatory cells and factors.
- Statins, known for their anti-inflammatory properties, are investigated for their potential to alleviate asthma symptoms.
Approach:
- A comprehensive meta-analysis was conducted, searching major scientific databases for studies on statin use in asthma patients.
- Twelve articles involving 613 participants were analyzed to assess the effects of statins on asthma symptoms, lung function, and various biomarkers.
Key Points:
- Statins significantly improved asthma symptoms, as indicated by changes in Asthma Control Questionnaire (ACQ) and Asthma Control Test (ACT) scores.
- Treatment with statins led to a significant reduction in serum high-sensitivity C-reactive protein (hsCRP) and cholesterol levels.
- A notable decrease was observed in the proportion of sputum eosinophils and interleukin-6 (IL-6) levels in sputum.
Conclusions:
- Statins demonstrate efficacy in improving asthma symptom control and reducing key inflammatory markers.
- Despite improvements in symptoms and inflammation, statins did not show a significant effect on lung function parameters in asthma patients.
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