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Ferroptosis in AS progression: role of miRNA
1Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Department of Pathophysiology, Department of Bioinformatics and Medical Big Data, Hengyang Medical School, University of South China, Hengyang, Hunan, China. ghli@usc.edu.cn.
Abstract:
We review the relationship between miRNAs associated with ferroptosis and the evolution of AS. Even though, more evidence is asked to determine the role of miRNAs associated with ferroptosis in the AS, this review will help us understand the role of miRNAs in ferroptosis and AS and may provide new insights for probing new biomarkers for the diagnosis and treatment of AS for the time to come. This is a narrative essay. Using PubMed as the main source, a literature search strategy was randomly implemented to index Scopus articles. No specific terminology is used. Studies have shown that ferroptosis plays a crucial role in the development of AS, and a large amount of ferroptosis in cells can lead to the progression of AS. MicroRNAs (MiRNAs) have been proved to be taken part in the biological course of ferroptosis and thus the process of AS is affected. The exact regulatory mechanism behind this appearance remains unclear. In order to clarify this, a growing number of studies have concentrated the regulatory role of miRNAs in the process of generation and development of ferroptosis, as well as the function of ferroptosis in the progression of AS. MiRNAs play a significant role in the process of ferroptosis and are incredibly significant in the occurrence, development, clinical diagnosis, treatment and prognosis evaluation of AS.
Insights
MicroRNAs (miRNAs) are involved in ferroptosis, a process crucial for Atherosclerosis (AS) development. Understanding this link may reveal new diagnostic and therapeutic biomarkers for AS.
Area of Science:
- Biochemistry
- Molecular Biology
- Cardiovascular Research
Background:
- Atherosclerosis (AS) progression is linked to ferroptosis, an iron-dependent cell death pathway.
- MicroRNAs (miRNAs) are implicated in regulating ferroptosis and consequently impact AS pathogenesis.
Approach:
- This narrative review synthesizes current literature on the interplay between miRNAs, ferroptosis, and AS.
- Literature search primarily utilized PubMed, supplemented by Scopus indexed articles.
Key Points:
- Ferroptosis significantly contributes to the development and progression of AS.
- MiRNAs regulate ferroptosis, thereby influencing AS development.
- The precise molecular mechanisms connecting miRNAs, ferroptosis, and AS require further elucidation.
Conclusions:
- MiRNAs play a critical role in ferroptosis and are significant in AS occurrence, development, diagnosis, treatment, and prognosis.
- Further research into miRNA-mediated ferroptosis could yield novel biomarkers for AS management.
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