Related Experiment Video
Updated: Aug 19, 2025
Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
Prognostic value of LncRNA-HOTAIR for patients with hepatocellular carcinoma: a meta-analysis
1Department of Hepatobiliary Surgery, Wuwei Liangzhou Hospital, Wuwei, Gansu, China. lzyylyh@163.com.
Insights
High expression of long non-coding RNA HOTAIR indicates a poorer prognosis in hepatocellular carcinoma (HCC) patients. This finding supports HOTAIR as a valuable prognostic biomarker for predicting unfavorable outcomes in HCC.
Area of Science:
- Oncology
- Molecular Biology
- Biomarkers
Background:
- Hepatocellular carcinoma (HCC) is a significant global health concern.
- Identifying reliable prognostic markers is crucial for improving patient outcomes.
- Long non-coding RNAs (lncRNAs) are emerging as important regulators in cancer development and progression.
Conclusions:
- High lncRNA-HOTAIR expression is a significant indicator of unfavorable prognosis in HCC.
- lncRNA-HOTAIR demonstrates clear prognostic value for predicting adverse outcomes in patients with hepatocellular carcinoma.
- This meta-analysis supports the utility of lncRNA-HOTAIR as a potential biomarker for HCC prognosis.
Objective:
This study aims at evaluating the prognostic value of LncRNA-HOTAIR for patients with hepatocellular carcinoma (HCC).
Materials And Methods:
A comprehensive databases and literature search was performed on PubMed, EMBASE, Web of Science, the Cochrane Library, CNKI, CBM, Wanfang, and VIP database up to the end of February 2022, for published studies on the connection of HCC and HOTAIR. STATA 12.0 software was used for the meta-analysis.
Results:
Eight studies with 412 patients were selected to be entered in the meta-analysis. We found that high expression of HOTAIR was associated with III+IV tumor stage (HR=2.31, 95% CI:1.32, 4.01), and it was not associated with age (HR=0.86, 95% CI:0.55, 1.34), gender (HR=0.91, 95% CI:0.55, 1.46), tumor number (HR=1.58, 95% CI:0.72, 3.48), tumor size (HR=1.54, 95% CI:0.96, 2.49), lymph node metastasis (HR=0.66, 95% CI:0.38, 1.15), AFP (HR=0.81, 95% CI:0.46, 1.42), cirrhosis (HR=1.34, 95% CI:0.75, 2.41), or portal invasion (HR=1.76, 95% CI:0.83, 3.72). A high expression level of HOTAIR was associated with a poorer OS (HR=3.12, 95% CI:1.31-7.43, p=0.010) and RFS (HR=1.67, 95% CI:1.23-2.26, p=0.010) for patients with HCC.
Conclusions:
A high expression level of HOTAIR was associated with III+IV tumor stage. Our meta-analysis clearly supports the prognostic value of HOTAIR to predict unfavorable prognostic outcomes for patients with HCC.
