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Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....

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Updated: Aug 19, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Management of systemic prostate cancer: current algorithm from castration sensitive to castration resistant setting.

C D'Aniello¹, C Cavaliere, C Foglia

¹Division of Medical Oncology, AORN dei Colli Ospedali Monaldi-Cotugno-CTO, Naples, Italy. carla.cavaliere@hotmail.it.

European Review for Medical and Pharmacological Sciences

|December 2, 2022

Summary

Recent advances in prostate cancer knowledge have introduced new treatments and strategies for managing systemic disease. This review integrates these developments for improved medical management of castration-sensitive and castration-resistant prostate cancer.

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Murine Prostate Micro-dissection and Surgical Castration

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Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

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Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Area of Science:

Oncology
Medical Science

Background:

Growing understanding of prostate cancer's clinical, biological, and molecular aspects.
Emergence of new treatment paradigms for systemic prostate cancer, including high-risk/high-volume versus low-risk/low-volume disease.

Approach:

Reviewing and integrating recent advancements in prostate cancer drug development and application.
Exploring the evolving landscape of systemic disease management and sequence therapy.

Key Points:

New drugs and repurposed existing drugs are changing treatment settings for prostate cancer.
Distinguishing between high-risk/high-volume and low-risk/low-volume castration-sensitive prostate cancer (CSPC) impacts treatment.
Previously approved drugs for castration-resistant prostate cancer (CRPC) are being reconsidered, opening new therapeutic sequences.

Conclusions:

The integration of new knowledge is crucial for optimizing medical management of systemic prostate cancer.
Evolving treatment strategies offer new possibilities for sequence therapy in advanced prostate cancer.