Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glomerular Filtration01:15

Glomerular Filtration

1.9K
The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.
1.9K
Glomerular Filtration: Net Filtration Pressure01:26

Glomerular Filtration: Net Filtration Pressure

3.3K
Glomerular filtration, a key process in the kidneys, is regulated by three main pressures: Glomerular blood hydrostatic pressure (GBHP), Capsular hydrostatic pressure (CHP), and Blood colloid osmotic pressure (BCOP).
GBHP, with an average value of 55 mmHg, promotes filtration by pushing water and solutes through the filtration membrane. This is balanced by two opposing forces: CHP, a "back pressure" exerted against the filtration membrane by fluid already in the capsular space and renal...
3.3K
Renal Drug Excretion: Glomerular Filtration01:02

Renal Drug Excretion: Glomerular Filtration

413
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
413
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

3.1K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.1K
Renal Corpuscle01:20

Renal Corpuscle

3.0K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.0K
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

59
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
59

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges of kidney function evaluation in pregnancy.

Journal of nephrology·2026
Same author

GFR indexing per Body surface area -Why, how and when?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Recalibration of the European Kidney Function Consortium eGFR Equation for the Indian Population.

Kidney international reports·2026
Same author

The evolving field of nephrology: what comes next? A report from the European Renal Association Scientific Advisory Board.

Clinical kidney journal·2026
Same author

From creatinine standardization to standardized eGFR reporting, European laboratory medicine is now completing the picture.

Clinical chemistry and laboratory medicine·2026
Same author

Performance of creatinine and cystatin C-based equations for estimating high levels of glomerular filtration rate in Congolese adults with sickle cell disease.

Clinical kidney journal·2026

Related Experiment Video

Updated: Aug 19, 2025

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K

Glomerular hyperfiltration: part 1 - defining the threshold - is the sky the limit?

Hans Pottel1, Oyindamola C Adebayo2,3, Agathe B Nkoy3,4

  • 1Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Etienne Sabbelaan 53, 8500, Kortrijk, Belgium. hans.pottel@kuleuven.be.

Pediatric Nephrology (Berlin, Germany)
|December 2, 2022
PubMed
Summary

Glomerular hyperfiltration (GHF) is defined as an elevated single-nephron GFR. For children over 2 years, a consensus threshold of 135 mL/min/1.73 m² is established, with specific diagnostic considerations for low muscle mass.

Keywords:
GHF thresholdGlomerular hyperfiltrationPediatric population

More Related Videos

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

13.8K
Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats
11:13

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats

Published on: April 17, 2013

10.6K

Related Experiment Videos

Last Updated: Aug 19, 2025

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K
An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
10:14

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

13.8K
Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats
11:13

Quantifying Glomerular Permeability of Fluorescent Macromolecules Using 2-Photon Microscopy in Munich Wistar Rats

Published on: April 17, 2013

10.6K

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Renal Physiology

Background:

  • Glomerular hyperfiltration (GHF) signifies an increased single-nephron glomerular filtration rate (GFR).
  • Whole-kidney GHF is often used as a clinical surrogate for single-nephron GHF.
  • A definitive threshold for diagnosing GHF is currently lacking.

Purpose of the Study:

  • To establish a clear, evidence-based threshold for defining GHF.
  • To review existing literature, including systematic reviews and meta-analyses, for GHF diagnostic criteria.
  • To provide guidance on reliable GHF diagnosis in pediatric populations.

Main Methods:

  • Comprehensive literature review encompassing systematic reviews and meta-analyses.
  • Analysis of studies utilizing both measured GFR and estimated GFR (eGFR).
  • Evaluation of GHF diagnostic reliability across different populations and GFR estimation methods.

Main Results:

  • A consensus pediatric threshold for GHF was established at 135 mL/min/1.73 m² for children older than 2 years.
  • Serum creatinine (SCr)-based eGFR is unreliable for diagnosing GHF in individuals with reduced muscle mass.
  • Cystatin C-based eGFR or measured GFR are recommended for confirming GHF in specific populations.

Conclusions:

  • The established pediatric GHF threshold provides a reliable diagnostic benchmark.
  • Alternative GFR assessment methods are crucial for accurate GHF diagnosis in individuals with low muscle mass.
  • Further research may refine GHF diagnostic criteria across diverse age groups and clinical conditions.