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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
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Antiasthma Drugs: Muscarinic Receptor Antagonists01:20

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Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Asthma Detection Research Based on Voice Signal Processing and Machine Learning
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Recent miRNA Research in Asthma.

Rinku Sharma1, Anshul Tiwari1, Michael J McGeachie2

  • 1Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Current Allergy and Asthma Reports
|December 2, 2022
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) offer new insights into asthma gene regulation, impacting pathology and symptoms. These molecules are promising biomarkers for asthma status, severity, and treatment response.

Keywords:
AsthmaReviewmiRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • MicroRNAs (miRNAs) represent a key layer of gene regulation.
  • Dysregulation of miRNAs is implicated in the pathogenesis of various diseases, including asthma.

Purpose of the Study:

  • To review recent research on microRNAs in asthma.
  • To compile comprehensive tables of asthma-related miRNA findings.

Main Methods:

  • Systematic review of 63 recent studies and 14 reviews on asthma and miRNA research.
  • Summarization of findings across adult and childhood asthma, asthma-COPD overlap syndrome (ACOs), and virus-induced asthma exacerbations.

Main Results:

  • Identified numerous miRNAs involved in asthma pathology and symptom development.
  • Documented the role of miRNAs in influencing biological mechanisms underlying asthma.
  • Highlighted the potential of miRNAs as biomarkers for asthma status, severity, and treatment response.

Conclusions:

  • MicroRNAs are crucial regulators in asthma, offering insights into disease mechanisms.
  • miRNAs show significant potential as diagnostic and prognostic biomarkers in asthma management.