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Related Experiment Video

Updated: Aug 19, 2025

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

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The Resistance Exercise in Already Active Diabetic Individuals (READI) Randomized Clinical Trial.

Ronald J Sigal^1,2,3, Jane E Yardley^2,4,5, Bruce A Perkins⁶

¹Departments of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB T2T 5C7, Canada.

The Journal of Clinical Endocrinology and Metabolism

|December 2, 2022

Summary

Adding resistance training to aerobic exercise did not change blood sugar levels (HbA1c) in type 1 diabetes patients. However, it did improve muscular strength and reduce waist circumference.

Keywords:

HbA1c exercise training physical activity strength training type 1 diabetes

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Area of Science:

Endocrinology
Exercise Physiology
Metabolic Diseases

Background:

Aerobic exercise is recommended for type 1 diabetes management.
The added benefits of resistance training for already aerobically active individuals with type 1 diabetes are not well-established.

Purpose of the Study:

To assess the incremental impact of adding resistance training to regular aerobic exercise in type 1 diabetes patients.
To evaluate changes in glycated hemoglobin A1c (HbA1c), cardiorespiratory fitness, body composition, and cardiometabolic risk factors.

Main Methods:

The READI trial was a 4-center, randomized trial involving 131 aerobically active individuals with type 1 diabetes.
Participants were assigned to either a resistance exercise group (n=71) or a control group (n=60) for 22 weeks, maintaining their aerobic activity.
Primary outcome was HbA1c; secondary outcomes included fitness, body composition, and cardiometabolic markers.

Main Results:

No significant differences in HbA1c reduction were observed between the resistance training and control groups.
The resistance training group showed significant improvements in muscular strength (P < .001) and a greater reduction in waist circumference (P = .02).
No intergroup differences were found in hypoglycemia or other measured variables.

Conclusions:

Incorporating resistance training into an established aerobic exercise regimen does not further improve glycemic control in type 1 diabetes.
Resistance exercise offers benefits for individuals with type 1 diabetes by enhancing muscular strength and improving body composition (reduced waist circumference).