Related Experiment Video

Updated: Aug 19, 2025

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

4.9K

Invasive fungal rhinosinusitis associated with COVID-19: Course changes and prognosis predictors

Maurizio Barbara1, Saad Elzayat2, Ashraf Lotfy3

  • 1ENT Clinic, NEMOS Department, Sant Andrea University Hospital, Sapienza University, Rome, Italy.

Acta Otorrinolaringologica Espanola
|December 2, 2022
PubMed
Abstract

Insights

This study analyzed acute invasive fungal rhinosinusitis (AIFRS) in COVID-19 patients, finding high mortality. Prolonged corticosteroid use worsened outcomes, while good glycemic control and specific antifungal treatments improved survival rates in AIFRS cases.

Area of Science:

  • Infectious Diseases
  • Otolaryngology
  • Critical Care Medicine

Background:

  • An increase in acute invasive fungal rhinosinusitis (AIFRS) cases has been observed, particularly in association with COVID-19 infection.
  • This study investigates factors influencing the prognosis of AIFRS in COVID-19 patients.

Purpose of the Study:

  • To analyze the behavior and outcomes of AIFRS in patients with COVID-19.
  • To identify key factors impacting patient prognosis and survival.

Main Methods:

  • A retrospective observational study involving 66 patients with AIFRS and confirmed COVID-19 across four tertiary institutions (November 2020 - February 2022).
  • Six-month follow-up data were collected and analyzed, correlating prognosis with demographic, clinical, laboratory, fungal, and management factors.

Main Results:

  • The study reported a 36% mortality rate among patients with AIFRS associated with COVID-19.
  • High-dose, prolonged corticosteroid use was identified as a significant negative prognostic factor.
  • Glycated hemoglobin A1c (HbA1c) levels below 9.35% showed 87.5% sensitivity for predicting survival.

Conclusions:

  • AIFRS in COVID-19 patients carries a high mortality rate.
  • Glycemic control, fungal species, and antifungal therapy type significantly influence AIFRS behavior.
  • Early surgical intervention, combination antifungal therapy (Amphotericin B and Voriconazole), and anticoagulants improved patient outcomes.
Keywords:
AnticoagulantesAnticoagulantsCOVID-19CorticoidesCorticosteroidsDMInvasive fungal rhino-sinusitisPrognosisPronósticoRinosinusitis fúngica invasiva

More Related Videos

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

1.5K
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.1K

Related Concept Videos

Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
423
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
433
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
352
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
210
Epistaxis01:30

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
231
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
423