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Updated: Aug 19, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

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Circulating progenitor cells and outcomes in patients with coronary artery disease

Devinder S Dhindsa1, Shivang R Desai1, Qingchun Jin2

  • 1Emory Clinical Cardiovascular Research Institute, Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

International Journal of Cardiology
|December 2, 2022
PubMed

Insights

Low circulating progenitor cells (CPCs) indicate poor regenerative capacity. Reduced counts of CD34+/CXCR4+ and CD34+/VEGFR2+ CPCs predict increased mortality and cardiovascular risk in coronary artery disease patients.

Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Low circulating progenitor cell (CPC) counts, particularly CD34+ populations, signify impaired intrinsic regenerative capacity.
  • This study explores the association between specific CPC subsets and adverse clinical outcomes.

Purpose of the Study:

  • To investigate the relationship between hematopoietic and endothelial CPC subsets and adverse outcomes in patients with coronary artery disease (CAD).
  • To determine if CPC levels can predict mortality and major adverse cardiovascular events.

Main Methods:

  • 1366 patients undergoing angiography for CAD were analyzed using flow cytometry to identify CPCs (CD45med, CD34+).
  • Hematopoietic CPCs were quantified as CD133+/CXCR4+ and endothelial CPCs as VEGFR2+.
  • Cox or Fine and Gray regression models assessed the association between CPC levels and all-cause death or a composite of cardiovascular death/myocardial infarction.

Main Results:

  • Over a median 3.1-year follow-up, lower counts of CD34+/CXCR4+ and CD34+/VEGFR2+ CPCs independently predicted higher all-cause mortality and cardiovascular death/MI.
  • A combination of low CD34+/CXCR4+ and CD34+/VEGFR2+ CPCs significantly increased the risk of all-cause death and cardiovascular death/MI.

Conclusions:

  • Diminished levels of hematopoietic and endothelial CPCs reflect reduced endogenous regenerative capacity.
  • Lower CPC counts are independently associated with increased mortality and cardiovascular risk in patients with CAD.
Abstract

Keywords:
BiomarkersCD34Coronary artery diseaseProgenitor cellsRisk assessment

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