Related Experiment Video
Updated: Oct 11, 2026

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
Published on: December 3, 2016
[Morphofunctional changes in the long tubular bones of animals which have developed while readapting after physical
Abstract:
The investigation has been performed on 120 white male rats of Wistar line. By means of the morphometry, electron microscopy and chemical methods dynamics of readaptive changes have been studied in long tubular bones during the period, when the effect of physical loadings both of dynamic and static character and of various intensity has been stopped, up to the old periods of the animals' life. Readaptation after moderate dynamic and static loadings is occurring for a long time and steadily. The changes caused by static loadings are nearly completely restored in a year. Morphofunctional rearrangements of the long tubular bones in the readaptation process after moderate dynamic loadings is characterized by residual manifestations. Prolonged readaptation after intensive physical loadings does not result in a complete restoration of all the parameters studied concerning growth and skeletal development. An intensive dynamic loading produces more stable changes, that are not subjected to a complete correction even after a passive readaptation for a year. Readaptation morphofunctional rearrangements of the long tubular skeletal bones depend on conditions of the previous regimen of the motor activity.
Related Concept Videos
Bone Remodeling
Classification of Bones
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Formation by Endochondral Ossification

