Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interlayer Confinement Steers Peracetic Acid Activation Toward Nearly Exclusive Singlet Oxygen Generation.

Angewandte Chemie (International ed. in English)·2026
Same author

Resveratrol Exerts Anti-Aging Effects in Young but Pro-Aging Effects in Middle-Aged C. elegans via a Gerosuppressive daf-16/dod-6/sod-3 Axis.

Free radical biology & medicine·2026
Same author

"Just the Best Ones" combination: a new strategy for multi-epitope vaccine candidate based on immunoinformatics analysis to induce protective immunity against MRSA infection.

Microbiology spectrum·2026
Same author

Translational hydrogel platform for durable sealing and mechanical restoration of annular defects.

Materials today. Bio·2026
Same author

Deletion of <i>flgL</i> in <i>Mesorhizobium ciceri</i> USDA 3378 weakened competitive nodulation ability by reducing flagellum formation, biofilm formation, and extracellular polysaccharide secretion.

Applied and environmental microbiology·2026
Same author

Non-invasive Multimodal Cardiovascular Disease Detection Method Based on Comprehensive View Analysis.

Journal of imaging informatics in medicine·2026

Related Experiment Video

Updated: Aug 19, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

11.9K

Injectable PTHF-based thermogelling polyurethane implants for long-term intraocular application.

Kaiwen Zhang1,2, Zengping Liu3,4,5, Qianyu Lin1

  • 1Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore, 138634, Singapore.

Biomaterials Research
|December 2, 2022
PubMed
Summary

New polytetrahydrofuran (PTHF)-based hydrogels offer long-term intraocular support for up to three months. These injectable, biocompatible hydrogels provide sustained vitreous cavity stability and can be naturally bio-eroded without surgery.

Keywords:
ImplantLCST polymerSupramolecular hydrogelThermoresponsiveVitreous substitutes

More Related Videos

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

12.7K
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

6.7K

Related Experiment Videos

Last Updated: Aug 19, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

11.9K
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

12.7K
Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye
06:10

Encapsulated Cell Technology for the Delivery of Biologics to the Mouse Eye

Published on: March 30, 2020

6.7K

Area of Science:

  • Biomaterials Science
  • Ophthalmology
  • Polymer Chemistry

Background:

  • Hydrogels are promising for intraocular applications due to their high water content and vitreous mimicry.
  • Injectable thermosensitive hydrogels are ideal for drug delivery and treating posterior eye diseases.
  • Existing thermosensitive hydrogels lack the necessary stability for long-term intraocular support (≥3 months).

Purpose of the Study:

  • To develop and evaluate an injectable, thermosensitive hydrogel for long-term intraocular applications.
  • To assess the stability, biocompatibility, and degradation of a novel polytetrahydrofuran (PTHF)-based hydrogel in vivo.

Main Methods:

  • Synthesized an injectable PTHF-based thermosensitive hydrogel via polyurethane reaction.
  • Evaluated hydrogel injectability, rheological properties, and microstructure.
  • Assessed in vivo biocompatibility, stability, and retinal function in rabbit eyes.

Main Results:

  • PTHF block type and ratio modulated the thermogelation properties of polyurethane polymers.
  • PTHF-based hydrogels demonstrated excellent biocompatibility, maintaining normal retinal structure and function.
  • Hydrogel networks remained stable in the vitreous cavity for over 3 months, outperforming existing thermogels.
  • Polymers underwent natural bio-erosion for removal without surgical intervention.

Conclusions:

  • Incorporating hydrophobic bioinert blocks like PTHF enhances the in vivo stability of supramolecular hydrogels.
  • PTHF-based hydrogels show significant potential for long-term intraocular applications, offering sustained support and natural degradation.