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Photobiomodulation and nitric oxide signaling.

Satoshi Kashiwagi1, Atsuyo Morita2, Shinya Yokomizo3

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Summary

Low-power near-infrared (NIR) light therapy, or photobiomodulation (PBM), shows promise for treating cardiovascular diseases by increasing nitric oxide (NO) bioavailability and improving endothelial function.

Keywords:
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Area of Science:

  • Cardiovascular Science
  • Biomedical Engineering
  • Photomedicine

Background:

  • Endothelial nitric oxide (NO) deficiency is a key factor in cardiovascular diseases.
  • Therapeutic strategies to increase NO bioavailability have shown limited clinical success.
  • Photobiomodulation (PBM) using low-power near-infrared (NIR) light demonstrates beneficial effects.

Purpose of the Study:

  • To review recent findings on photobiomodulation (PBM) and its effects on nitric oxide (NO).
  • To explore the potential of PBM as a therapeutic approach for cardiovascular diseases.
  • To highlight the advantages of NIR-II window light for PBM.

Main Methods:

  • Review of recent scientific literature on PBM, NO, and endothelial function.
  • Analysis of studies investigating the mechanisms of PBM in relation to NO production.
  • Focus on the application of NIR light, particularly in the NIR-II window.

Main Results:

  • PBM consistently improves endothelial dysfunction by increasing bioavailable NO in a dose-dependent manner.
  • NIR light, especially in the NIR-II window (1000-1700 nm), offers enhanced tissue penetration and reduced absorption for PBM.
  • PBM presents a feasible therapeutic strategy for cardiovascular complications linked to NO deficiency.

Conclusions:

  • PBM is an emerging therapeutic modality for cardiovascular diseases.
  • Augmenting NO bioavailability through PBM offers a promising treatment avenue.
  • NIR-II window PBM holds significant potential due to its optimal light penetration properties.