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Clinical value of the platelet and inflammatory factor activation in vascular endothelial injury in essential

Zheng-Wei Jian1, Xiao-Ming Zhang1, Guan-Shen Huang2

  • 1Department of Cardiovascular Medicine, Affiliated Dongguan Hospital, Southern Medical University (Dongguan People's Hospital). Dongguan, Guangdong, China.

Clinical Hemorheology and Microcirculation
|December 4, 2022
PubMed

Insights

Platelet and inflammatory factor activation are linked to vascular endothelial injury in hypertension. These markers effectively indicate endothelial dysfunction, highlighting their clinical value in managing hypertension complications.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • Hypertension is a major risk factor for cardiovascular diseases, often associated with endothelial dysfunction.
  • Vascular endothelial injury plays a critical role in the pathogenesis and progression of hypertension-related complications.
  • Platelet activation and inflammatory responses are implicated in vascular damage, but their specific role in hypertension needs further elucidation.

Purpose of the Study:

  • To investigate the clinical significance of platelet activation markers and inflammatory factors in assessing vascular endothelial injury among hypertensive patients.
  • To determine the correlation between platelet activation, inflammatory markers, and endothelial function in hypertension.
  • To identify key indicators of platelet and inflammatory activation that predict endothelial dysfunction in hypertension.

Main Methods:

  • Recruited 120 hypertension patients and 60 healthy controls.
  • Measured mean platelet volume (MPV), platelet distribution width (PDW), platelet hematocrit (PCT), IL-6, IL-8, TNF-α, and reactive hyperemia index (RHI).
  • Employed regression and Spearman correlation analyses to assess relationships and risk factors.

Main Results:

  • Hypertension patients showed elevated MPV, PDW, PCT, IL-6, IL-8, TNF-α, and reduced RHI compared to controls.
  • Significant negative correlations were observed between MPV, PDW, PCT, IL-6, IL-8, TNF-α, and RHI.
  • MPV, PCT, IL-8, and TNF-α were identified as risk factors for vascular endothelial dysfunction.

Conclusions:

  • Platelet and inflammatory factor activation are closely associated with vascular endothelial injury in hypertension.
  • These activated markers serve as valuable indicators of endothelial dysfunction in hypertensive individuals.
  • The findings suggest potential therapeutic targets for mitigating vascular damage in hypertension.
Abstract

Keywords:
Platelet activationclinical valuehypertensioninflammatory factorsvascular endothelial injury

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