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Updated: Aug 19, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Knowledge Representation and Management: Notable Contributions in 2021
Licong Cui1, Ferdinand Dhombres2,3, Jean Charlet2,4
1School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Objectives:
To select, present, and summarize the best papers in the field of Knowledge Representation and Management (KRM) published in 2021.
Methods:
Following the International Medical Informatics Association (IMIA) Yearbook guidelines, a comprehensive and standardized review of the biomedical informatics literature was performed to select the best KRM papers published in 2021, based on PubMed queries.
Results:
A total of 1,231 publications were retrieved from PubMed. We nominated 15 candidate best papers, and four of them were finally selected as the best papers in the KRM section. The topics covered by these papers include knowledge graph, ontology development, ontology alignment, and the International Classification of Diseases.
Conclusion:
In the KRM best paper selection for 2021, the candidate best papers covered a wider spectrum of topics compared to the last year's significant focus on ontology curation. In particular, ontology development for specific domains (e.g., Alzheimer's disease, infectious diseases, bioethics) has received the most attention.
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