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Paper-based optical nanosensors - A review.

Forough Ghasemi1, Nafiseh Fahimi-Kashani2, Arafeh Bigdeli3

  • 1Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education, Extension Organization (AREEO), Karaj, 3135933151, Iran.

Analytica Chimica Acta
|December 4, 2022
PubMed
Summary

Paper-based nanosensors offer affordable, sensitive, and user-friendly optical detection for point-of-care applications. This review details their fabrication, signal generation, and diverse applications, highlighting future commercialization potential.

Keywords:
Colorimetric sensingLuminescence sensingNanostructuresOptical nanosensorsPaper-based analytical devices

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Paper-based analytical devices (PADs) are cost-effective, portable tools for on-site testing.
  • Optical sensors on paper meet ASSURED criteria for widespread use, especially in remote settings.
  • Nanostructures enhance optical signal intensity and tunability for improved sensor performance.

Purpose of the Study:

  • To review the fundamentals and state-of-the-art of paper-based nanosensors.
  • To comprehensively discuss fabrication, signal acquisition, and interpretation of optical PADs.
  • To explore application areas and future trends for commercializing nanosensor technology.

Main Methods:

  • Review of existing literature on paper-based analytical devices and nanosensors.
  • Analysis of nanostructure integration for optical signal generation in PADs.
  • Discussion of substrate materials, fabrication techniques, and data handling.

Main Results:

  • Nanostructures provide intense and tunable optical signals ideal for paper-based sensing platforms.
  • Various methods exist for fabricating optical PADs, including nanostructure stabilization.
  • PADs demonstrate significant potential across chemical, biochemical, and environmental sensing.

Conclusions:

  • Paper-based nanosensors are highly promising for point-of-care diagnostics and field detection.
  • Further development in fabrication and commercialization strategies is crucial for widespread adoption.
  • Nanosensor technology integrated with PADs offers a scalable and accessible analytical solution.