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Related Experiment Video

Updated: Aug 19, 2025

Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography
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Plasmonic Cyclic Au Nanosphere Hexamers.

Jeongwon Kim1, Sungwoo Lee1,2, Jiwoong Son3

  • 1Department of Chemistry, Sungkyunkwan University, Suwon, 16419, South Korea.

Small (Weinheim an Der Bergstrasse, Germany)
|December 4, 2022
PubMed
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Researchers developed plasmonic cyclic gold nanosphere hexamers (PCHs) for enhanced sensing. These PCHs offer superior surface-enhanced Raman scattering (SERS) signals, improving immunoassay sensitivity significantly.

Area of Science:

  • Colloidal chemistry
  • Nanotechnology
  • Plasmonics

Background:

  • Rational design of plasmonic colloidal assemblies is crucial for advanced optical properties.
  • Bottom-up synthesis offers a pathway to control assembly shape and spatial arrangement.
  • Existing methods face challenges in achieving precise control over complex plasmonic nanostructures.

Purpose of the Study:

  • To synthesize plasmonic cyclic gold nanosphere hexamers (PCHs) using a novel bottom-up approach.
  • To investigate the unique plasmonic characteristics arising from the PCH structure.
  • To evaluate the performance of PCHs as nanoprobes in surface-enhanced Raman scattering (SERS) based immunoassays.

Main Methods:

  • Synthesis of gold nanospheres (Au NSs) interconnected by thin metal ligaments.
Keywords:
goldplasmonicsplatinumsurface-enhanced Raman scattering (SERS)-based immunoassay

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  • Selective deposition of platinum (Pt) atoms on nanosphere edges.
  • Etching of a core hexagon nanoplate (NPL) to form necklace-like Pt frameworks.
  • Subsequent gold deposition to yield PCHs with high yield (≈90%).

    • Main Results:

    • Successfully synthesized PCHs exhibiting combinatorial plasmonic properties of individual Au NSs and in-plane coupling.
    • Achieved highly uniform, reproducible, and polarization-independent single-particle SERS signals.
    • Demonstrated the application of PCHs in a SERS-based immunoassay with a low limit-of-detection (100 pM).

    Conclusions:

    • PCHs offer superior SERS performance compared to individual Au NSs and smooth Au nanorings.
    • The 2D isotropic alignment of Au NSs in PCHs is key to their enhanced SERS capabilities.
    • PCHs represent promising nanoprobes for sensitive and reliable quantitative and qualitative immunoassays.