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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mesenchymal Stem Cells01:19

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Stem Cell Therapy in Lupus.

Xinran Yuan1, Lingyun Sun1

  • 1Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Rheumatology and Immunology Research
|December 5, 2022
PubMed
Summary
This summary is machine-generated.

Stem cell therapy offers a promising alternative for treating Systemic Lupus Erythematosus (SLE), a chronic autoimmune disease. Hematopoietic stem cell transplantation and mesenchymal stem cell transplantation are explored as potential treatments to improve recovery rates and reduce adverse events.

Keywords:
hematopoietic stem cellsmesenchymal stem cellsstem cell therapysystemic lupus erythematosustransplantation

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organ systems.
  • Current immunosuppressive therapies often fail to prevent disease relapse in over half of patients.
  • Stem cell therapy is emerging as a potential alternative treatment for refractory SLE.

Purpose of the Study:

  • To review stem cell sources and applications for SLE treatment.
  • To compare hematopoietic stem cell transplantation (HSCT) with mesenchymal stem cell transplantation (MSCT) for SLE.

Main Methods:

  • Review of animal studies and clinical trials on stem cell therapy for SLE.
  • Analysis of different stem cell types used in SLE treatment.
  • Comparative assessment of HSCT and MSCT efficacy and safety.

Main Results:

  • Stem cell therapy demonstrates promise in preclinical and clinical studies for SLE.
  • Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are key cell types investigated.
  • HSCT and MSCT show potential for improving outcomes in SLE patients.

Conclusions:

  • Stem cell therapy represents a viable alternative for managing SLE, potentially overcoming limitations of conventional treatments.
  • Further research and clinical trials are needed to optimize stem cell therapy protocols for SLE.
  • Both HSCT and MSCT warrant continued investigation for their role in SLE management.