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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
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Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease
Mary M Kavurma1, Christina Bursill2,3, Christopher P Stanley1
1Heart Research Institute, The University of Sydney, Sydney, NSW, Australia.
Frontiers in Cardiovascular Medicine
|December 5, 2022
Summary
Peripheral artery disease (PAD) involves narrowed arteries reducing lower limb blood flow. Correcting endothelial cell (EC) dysfunction offers a promising therapeutic target for PAD.
Area of Science:
- Vascular Biology
- Cardiovascular Medicine
Background:
- Peripheral artery disease (PAD) is characterized by reduced blood flow to the lower limbs due to arterial narrowing or occlusion.
- Current PAD treatments include lifestyle modifications, risk factor management, and surgical interventions.
Purpose of the Study:
- To review the contribution of endothelial cell (EC) dysfunction to PAD pathophysiology.
- To explore the therapeutic potential of correcting EC dysfunction in PAD.
- To discuss current and emerging treatments targeting EC dysfunction.
Main Methods:
- Literature review focusing on endothelial cell biology in PAD.
- Analysis of current clinical trials and therapeutic strategies.
- Identification of future research directions.
Main Results:
- Endothelial cell dysfunction is a key contributor to PAD development and progression.
- Targeting EC dysfunction presents a largely untapped therapeutic avenue for PAD.
- Several treatments and ongoing trials aim to improve EC function in PAD patients.
Conclusions:
- Endothelial cell dysfunction is a critical factor in PAD.
- Therapeutic strategies aimed at improving EC function hold significant promise for PAD treatment.
- Further research into EC-targeted therapies is warranted for effective PAD management.
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