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Does bone mobilization interfere with energy metabolism in transition cows?
M O Matthaei1, S U Kononov1, J Rehage2
1Institute of Animal Nutrition, Nutrition Diseases and Dietetics, Faculty of Veterinary Medicine, University of Leipzig, 01403 Leipzig, Saxony, Germany.
JDS Communications
|December 5, 2022
Summary
Low serum calcium in dairy cows before calving can precede energy metabolism issues. Bone turnover markers, like undercarboxylated osteocalcin (ucOC), also influence insulin sensitivity and cow health.
Area of Science:
- Animal Science
- Metabolic Diseases
- Mineral Homeostasis
Background:
- Lactation onset challenges mineral balance and energy metabolism in high-producing dairy cows.
- Hypocalcemia is linked to ketosis, and bone-derived factors may influence metabolism.
Purpose of the Study:
- Investigate the relationship between mineral homeostasis, bone turnover, and energy metabolism around calving.
- Analyze serum markers of calcium, bone turnover, and energy metabolism in multiparous dairy cows.
Main Methods:
- Collected serum samples from 15 cows at -7, -3, +1, +3, and +7 days relative to calving.
- Measured total calcium, CrossLaps, intact osteocalcin, undercarboxylated osteocalcin (ucOC), insulin, glucose, NEFA, BHB, and IGF-1.
- Grouped cows based on ucOC levels and assessed insulin sensitivity using RQUICKI.
Main Results:
- Serum calcium levels around calving correlated with energy metabolism parameters.
- Significant variations in ucOC were observed early, leading to distinct cow groups.
- Cows with high ucOC exhibited higher insulin sensitivity (RQUICKI) throughout the observation period.
Conclusions:
- Low serum calcium precedes disruptions in energy metabolism in dairy cows.
- Bone turnover markers, particularly ucOC, may be linked to insulin sensitivity.
- Further research is warranted to explore the interplay between mineral balance, bone turnover, and intermediary metabolism.
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