Related Experiment Video

Updated: Aug 19, 2025

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.9K

The Growth Factors: Potential Biomarkers and Therapeutic Targets in Kidney Diseases

Wei Tang1, Yufeng Zhang1, Sijia Cui1

  • 1Department of Pharmacology, The Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Sciences, Shandong University, Jinan, China.

Kidney Diseases (Basel, Switzerland)
|December 5, 2022
PubMed
Abstract

Insights

Growth factors are key in kidney disease development and progression. Research highlights their potential as diagnostic biomarkers and therapeutic targets for improved kidney disease management.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Kidney diseases represent a significant global health burden.
  • Current treatments for kidney disease are limited, necessitating advancements in early diagnosis and novel therapies.
  • Understanding kidney disease pathophysiology is crucial for developing effective interventions.

Purpose of the Study:

  • To review recent advances in the application of growth factors for kidney disease diagnosis and therapy.
  • To highlight the role of growth factors, receptors, and regulators as potential biomarkers and therapeutic targets.
  • To summarize the performance of growth factor-based strategies in clinical trials.

Main Methods:

  • Literature review of studies on growth factors in kidney diseases.
  • Analysis of research on growth factors as diagnostic biomarkers.
  • Evaluation of therapeutic interventions targeting growth factors in kidney disease.

Main Results:

  • Altered growth factor levels are detectable in circulation and urine of kidney disease patients.
  • Growth factors, receptors, and regulators show promise as diagnostic/prognostic biomarkers.
  • Growth factor-based therapies are being investigated for kidney disease treatment.

Conclusions:

  • Growth factors are integral to kidney disease development and progression.
  • Further understanding of growth factor-regulated pathways is needed for clinical translation.
  • Novel intervention approaches are essential for advancing growth factor-based diagnosis and therapy in kidney diseases.
Keywords:
Acute kidney injuryChronic kidney diseaseClinical trialsGrowth factors

More Related Videos

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.3K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

766

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
54
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
68
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
2.6K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
138
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
53
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
33