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Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
Published on: April 21, 2016
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Biomaterials and bioengineering to guide tissue morphogenesis in epithelial organoids
Eun Young Jeon1, Leila Sorrells2, Hasan Erbil Abaci1
1Dermatology Department, Columbia University Medical Center, New York, NY, United States.
Frontiers in Bioengineering and Biotechnology
|December 5, 2022
Summary
Organoid culture advances with biomaterials and microengineering. These technologies improve organoid development by mimicking the in vivo microenvironment for better tissue modeling and disease research.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Developmental Biology
Background:
- Organoids model organ development and disease but lack in vivo complexity.
- Current organoid cultures struggle with spatiotemporal control of biochemical and physical cues.
- Immature organoids limit their utility in recapitulating in vivo tissue development.
Purpose of the Study:
- Review advances in biomaterials and microengineering for organoid culture.
- Highlight the importance of understanding native extracellular matrix (ECM) for scaffold design.
- Discuss strategies to improve organoid morphogenesis and maturation.
Main Methods:
- Analysis of ECM diversity and organization in epithelial organs.
- Overview of hydrogel systems for epithelial organoid culture.
- Review of tissue engineering and microfabrication technologies (bioprinting, microfluidics).
Main Results:
- Biomaterials and microengineering enable better recapitulation of organ morphogenesis.
- Understanding native ECM guides the design of supportive scaffolds for organoid growth.
- Engineering approaches offer precise spatiotemporal control over organoid development.
Conclusions:
- Integrating engineering with organoids provides novel methods for instructing morphogenesis.
- Advanced techniques overcome limitations of traditional organoid cultures.
- High-throughput screening platforms can be established using these integrated systems.
