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Microglia autophagy in ischemic stroke: A double-edged sword
Li Peng1,2,3, Guangqiang Hu4, Qianfang Yao1,2
1Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, School of Pharmacy, Southwest Medical University, Luzhou, China.
Frontiers in Immunology
|December 5, 2022
Summary
Microglia play dual roles in ischemic stroke (IS) by aiding repair but also causing damage. Understanding microglia autophagy
Area of Science:
- Neuroscience
- Immunology
- Pathology
Background:
- Ischemic stroke (IS) is a leading cause of global mortality and morbidity.
- Microglia, the brain's immune cells, exhibit both protective and detrimental functions in IS.
- Inflammation is a key feature of IS, involving microglial activation.
Purpose of the Study:
- To review the dual roles of microglia in ischemic stroke.
- To explore the interaction between microglial autophagy and inflammation in IS.
- To discuss therapeutic strategies targeting microglia for IS treatment.
Main Methods:
- Literature review of studies on microglia, autophagy, and inflammation in IS.
- Analysis of the molecular mechanisms underlying microglial functions in IS.
- Synthesis of current research on therapeutic interventions.
Main Results:
- Microglia can promote tissue repair but also contribute to secondary brain damage in IS.
- Autophagy in microglia modulates inflammatory responses during ischemic events.
- The interplay between microglia autophagy and inflammation offers potential therapeutic targets.
Conclusions:
- Modulating microglial autophagy presents a promising avenue for IS treatment.
- Further research is needed to fully elucidate the complex roles of microglia in IS.
- Targeting the autophagy-inflammation axis in microglia could improve IS outcomes.
