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Curcumol repressed cell proliferation and angiogenesis via SP1/mir-125b-5p/VEGFA axis in non-small cell lung cancer

Changju Ma1,2, Xiaojuan Tang2,3, Qing Tang2,4,5

  • 1The Postdoctoral Research Station, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in Pharmacology
|December 5, 2022
PubMed

Insights

Curcumol inhibits non-small cell lung cancer (NSCLC) growth and spread by targeting the SP1/miR-125b-5p/VEGFA pathway. This study reveals Curcumol as a potential therapeutic agent for NSCLC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Non-small cell lung cancer (NSCLC) presents a significant global health challenge with poor survival rates.
  • Curcumol exhibits potential antitumor properties, but its efficacy and mechanism in NSCLC require elucidation.

Purpose of the Study:

  • To investigate the anti-cancer effects of Curcumol on NSCLC cells.
  • To explore the underlying molecular mechanisms, including the roles of SP1, miR-125b-5p, and VEGFA.

Main Methods:

  • Cell proliferation, migration, and invasion assays were performed on NSCLC cell lines.
  • Tube formation and wound healing assays assessed effects on human umbilical vein endothelial cells (HUVECs).
  • Quantitative analysis of SP1, miR-125b-5p, and VEGFA expression levels was conducted.

Main Results:

  • Curcumol significantly inhibited NSCLC cell proliferation, migration, and invasion.
  • Curcumol downregulated SP1 and VEGFA expression while upregulating miR-125b-5p in NSCLC cells.
  • Overexpression of SP1 or inhibition of miR-125b-5p partially reversed Curcumol's inhibitory effects.

Conclusions:

  • Curcumol demonstrates potent anti-cancer activity against NSCLC by modulating the SP1/miR-125b-5p/VEGFA axis.
  • Curcumol inhibits angiogenesis, suggesting its therapeutic potential for NSCLC treatment.
Keywords:
NSCLCSp1VEGFAangiogenesiscurcumolmiR-125b-5ptumor microenvironment

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