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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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A long non-coding RNA with important roles in the carcinogenesis.
Soudeh Ghafouri-Fard1, Arian Askari2, Bashdar Mahmud Hussen3,4
1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Frontiers in Cell and Developmental Biology
|December 5, 2022
Summary
Long non-coding RNAs like TMPO-AS1 play a role in cancer development. This review explores TMPO-AS1
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their involvement in carcinogenesis.
- TMPO Antisense RNA 1 (TMPO-AS1) is a lncRNA implicated in cancer progression.
Purpose of the Study:
- To review the multifaceted role of TMPO-AS1 in the development of various cancers.
- To evaluate TMPO-AS1 as a potential biomarker for cancer diagnosis and prognosis.
Main Methods:
- Literature review of studies investigating TMPO-AS1 function in cancer.
- Analysis of TMPO-AS1's molecular mechanisms, including its role as a microRNA sponge and its impact on signaling pathways.
Main Results:
- TMPO-AS1 acts as a molecular sponge for numerous microRNAs (e.g., miR-320a, miR-383-5p, miR-143-3p).
- TMPO-AS1 influences the PI3K/Akt/mTOR signaling pathway, a critical regulator of cell growth and survival.
- Evidence suggests TMPO-AS1's dysregulation in multiple cancer types.
Conclusions:
- TMPO-AS1 is a significant contributor to carcinogenesis through its regulatory functions.
- TMPO-AS1 holds promise as a diagnostic and prognostic biomarker for cancer patients.
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