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A long non-coding RNA with important roles in the carcinogenesis

Soudeh Ghafouri-Fard1, Arian Askari2, Bashdar Mahmud Hussen3,4

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Cell and Developmental Biology
|December 5, 2022
PubMed

Insights

Long non-coding RNAs like TMPO-AS1 play a role in cancer development. This review explores TMPO-AS1

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their involvement in carcinogenesis.
  • TMPO Antisense RNA 1 (TMPO-AS1) is a lncRNA implicated in cancer progression.

Purpose of the Study:

  • To review the multifaceted role of TMPO-AS1 in the development of various cancers.
  • To evaluate TMPO-AS1 as a potential biomarker for cancer diagnosis and prognosis.

Main Methods:

  • Literature review of studies investigating TMPO-AS1 function in cancer.
  • Analysis of TMPO-AS1's molecular mechanisms, including its role as a microRNA sponge and its impact on signaling pathways.

Main Results:

  • TMPO-AS1 acts as a molecular sponge for numerous microRNAs (e.g., miR-320a, miR-383-5p, miR-143-3p).
  • TMPO-AS1 influences the PI3K/Akt/mTOR signaling pathway, a critical regulator of cell growth and survival.
  • Evidence suggests TMPO-AS1's dysregulation in multiple cancer types.

Conclusions:

  • TMPO-AS1 is a significant contributor to carcinogenesis through its regulatory functions.
  • TMPO-AS1 holds promise as a diagnostic and prognostic biomarker for cancer patients.
Keywords:
TMPO-AS1biomarkercancerexpressionlncRNA

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