Infantile epileptic spasms syndrome as an initial presentation in infantile choroid plexus papilloma: A case report

Area of Science:

• Neuroscience
• Pediatric Neurology
• Developmental Pediatrics

Background:

• Epileptic spasms in infants can be challenging to manage, often requiring extensive diagnostic workups.
• Developmental delay is a significant concern in pediatric neurology, necessitating identification of underlying causes.
• Ventriculomegaly, an enlargement of the brain's ventricles, can be detected prenatally and warrants further investigation.

Observation:

• A 5-month-old infant presented with a history of epileptic spasms and developmental delay.
• Prenatal imaging revealed non-isolated ventriculomegaly.
• Brain magnetic resonance imaging (MRI) identified a right ventricular choroid plexus papilloma (CPP).

Findings:

• The infant's epileptic spasms were refractory to multiple antiepileptic drug therapies.
• Following surgical removal of the choroid plexus papilloma, the infant's epileptic spasms resolved completely.
• This suggests a direct causal link between the CPP and the infantile spasms.

Implications:

• Choroid plexus papillomas should be considered in the differential diagnosis of infantile spasms, especially when associated with ventriculomegaly.
• Early diagnosis and surgical intervention for CPP may lead to favorable neurological outcomes in affected infants.
• This case highlights the importance of comprehensive neuroimaging in infants with refractory epilepsy and developmental concerns.