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Bibliometric and Visualized Analysis of the Current Status on STING Signaling Pathway and Cancer

Zhongqi Lu1,2, Qiang Fu1,2, Jinyuan Sui2

  • 1Department of Ultrasound Medicine, Affiliated Hospital of Yanbian University, Yanji 133000, Jilin, China.

Journal of Oncology
|December 5, 2022
PubMed

Insights

The interferon gene stimulating factor (STING) pathway plays a complex role in cancer. Research shows STING

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Cancer remains a leading global cause of death, driving urgent research into novel treatment strategies.
  • Immunotherapy has emerged as a significant focus in cancer treatment research.
  • The interferon gene stimulating factor (STING) signaling pathway exhibits a complex, context-dependent role in cancer progression and suppression.

Purpose of the Study:

  • To analyze the research landscape of the STING signaling pathway in cancer from 2008 to 2022.
  • To identify current research trends, collaborations, and hotspots in STING-mediated cancer research.
  • To predict future research directions for the STING pathway in oncology.

Main Methods:

  • Bibliometric analysis of scientific literature on cancer and the STING signaling pathway.
  • Utilized CiteSpace software for visualization and analysis of research trends and collaborations.
  • Literature review covering the period 2008-2022.

Main Results:

  • The STING signaling pathway is a rapidly expanding area of cancer research.
  • Significant research focus has shifted towards STING's role in the tumor microenvironment.
  • The involvement of STING in immunotherapy has become a prominent and growing research hotspot.

Conclusions:

  • The STING signaling pathway is increasingly recognized for its critical roles in cancer.
  • Future research will likely concentrate on leveraging STING for enhanced tumor microenvironment modulation and immunotherapy efficacy.
  • Continued high attention is expected for STING pathway research in oncology.

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